Meeting the challenge of hematologic malignancies in sub-Saharan Africa
Identifieur interne : 000362 ( Main/Exploration ); précédent : 000361; suivant : 000363Meeting the challenge of hematologic malignancies in sub-Saharan Africa
Auteurs : Satish Gopal [États-Unis] ; William A. Wood ; Stephanie J. Lee [États-Unis] ; Thomas C. Shea ; Kikkeri N. Naresh [Royaume-Uni] ; Peter N. Kazembe [Malawi] ; Corey Casper [États-Unis] ; Peter B. Hesseling [Afrique du Sud] ; Ronald T. Mitsuyasu [États-Unis]Source :
- Blood [ 0006-4971 ] ; 2012.
Abstract
Cancer is a leading cause of death and disability in sub-Saharan Africa and will eclipse infectious diseases within the next several decades if current trends continue. Hematologic malignancies, including non-Hodgkin lymphoma, leukemia, Hodgkin lymphoma, and multiple myeloma, account for nearly 10% of the overall cancer burden in the region, and the incidence of non-Hodgkin lymphoma and Hodgkin lymphoma is rapidly increasing as a result of HIV. Despite an increasing burden, mechanisms for diagnosing, treating, and palliating malignant hematologic disorders are inadequate. In this review, we describe the scope of the problem, including the impact of endemic infections, such as HIV, Epstein-Barr virus, malaria, and Kaposi sarcoma–associated herpesvirus. We additionally describe current limitations in hematopathology, chemotherapy, radiotherapy, hematopoietic stem cell transplantation, and supportive care and palliation. We review contemporary treatment and outcomes of hematologic malignancies in the region and outline a clinical service and research agenda, which builds on recent global health successes combating HIV and other infectious diseases. Achieving similar progress against hematologic cancers in sub-Saharan Africa will require the sustained collaboration and advocacy of the entire global cancer community.
Url:
DOI: 10.1182/blood-2012-02-387092
PubMed: 22461494
PubMed Central: 4507039
Affiliations:
- Afrique du Sud, Malawi, Royaume-Uni, États-Unis
- Angleterre, Californie, Caroline du Nord, Grand Londres, Washington (État)
- Londres
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Wood</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Lineberger Comprehensive Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name><affiliation wicri:level="2"><nlm:aff id="aff3">Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Shea, Thomas C" sort="Shea, Thomas C" uniqKey="Shea T" first="Thomas C." last="Shea">Thomas C. Shea</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Lineberger Comprehensive Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Naresh, Kikkeri N" sort="Naresh, Kikkeri N" uniqKey="Naresh K" first="Kikkeri N." last="Naresh">Kikkeri N. 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Kazembe</name><affiliation wicri:level="1"><nlm:aff id="aff5">Baylor International Pediatric AIDS Initiative, Lilongwe, Malawi;</nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Baylor International Pediatric AIDS Initiative, Lilongwe</wicri:regionArea><wicri:noRegion>Lilongwe</wicri:noRegion></affiliation></author><author><name sortKey="Casper, Corey" sort="Casper, Corey" uniqKey="Casper C" first="Corey" last="Casper">Corey Casper</name><affiliation wicri:level="2"><nlm:aff id="aff6">Vaccine and Infectious Disease, Public Health Science and Clinical Research Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Vaccine and Infectious Disease, Public Health Science and Clinical Research Divisions, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7">Departments of Medicine, Epidemiology, and Global Health, University of Washington, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Medicine, Epidemiology, and Global Health, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Hesseling, Peter B" sort="Hesseling, Peter B" uniqKey="Hesseling P" first="Peter B." last="Hesseling">Peter B. Hesseling</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff8">Department of Pediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa</nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Pediatrics and Child Health, Stellenbosch University, Stellenbosch</wicri:regionArea><wicri:noRegion>Stellenbosch</wicri:noRegion></affiliation></author><author><name sortKey="Mitsuyasu, Ronald T" sort="Mitsuyasu, Ronald T" uniqKey="Mitsuyasu R" first="Ronald T." last="Mitsuyasu">Ronald T. Mitsuyasu</name><affiliation wicri:level="2"><nlm:aff id="aff9">David Geffen School of Medicine, Center for Clinical AIDS Research and Education, University of California, Los Angeles, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>David Geffen School of Medicine, Center for Clinical AIDS Research and Education, University of California, Los Angeles, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cancer is a leading cause of death and disability in sub-Saharan Africa and will eclipse infectious diseases within the next several decades if current trends continue. Hematologic malignancies, including non-Hodgkin lymphoma, leukemia, Hodgkin lymphoma, and multiple myeloma, account for nearly 10% of the overall cancer burden in the region, and the incidence of non-Hodgkin lymphoma and Hodgkin lymphoma is rapidly increasing as a result of HIV. Despite an increasing burden, mechanisms for diagnosing, treating, and palliating malignant hematologic disorders are inadequate. In this review, we describe the scope of the problem, including the impact of endemic infections, such as HIV, Epstein-Barr virus, malaria, and Kaposi sarcoma–associated herpesvirus. We additionally describe current limitations in hematopathology, chemotherapy, radiotherapy, hematopoietic stem cell transplantation, and supportive care and palliation. We review contemporary treatment and outcomes of hematologic malignancies in the region and outline a clinical service and research agenda, which builds on recent global health successes combating HIV and other infectious diseases. Achieving similar progress against hematologic cancers in sub-Saharan Africa will require the sustained collaboration and advocacy of the entire global cancer community.</p></div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Malawi</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Caroline du Nord</li><li>Grand Londres</li><li>Washington (État)</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Shea, Thomas C" sort="Shea, Thomas C" uniqKey="Shea T" first="Thomas C." last="Shea">Thomas C. Shea</name><name sortKey="Wood, William A" sort="Wood, William A" uniqKey="Wood W" first="William A." last="Wood">William A. Wood</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Gopal, Satish" sort="Gopal, Satish" uniqKey="Gopal S" first="Satish" last="Gopal">Satish Gopal</name></region><name sortKey="Casper, Corey" sort="Casper, Corey" uniqKey="Casper C" first="Corey" last="Casper">Corey Casper</name><name sortKey="Casper, Corey" sort="Casper, Corey" uniqKey="Casper C" first="Corey" last="Casper">Corey Casper</name><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name><name sortKey="Mitsuyasu, Ronald T" sort="Mitsuyasu, Ronald T" uniqKey="Mitsuyasu R" first="Ronald T." last="Mitsuyasu">Ronald T. Mitsuyasu</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Naresh, Kikkeri N" sort="Naresh, Kikkeri N" uniqKey="Naresh K" first="Kikkeri N." last="Naresh">Kikkeri N. Naresh</name></region></country><country name="Malawi"><noRegion><name sortKey="Kazembe, Peter N" sort="Kazembe, Peter N" uniqKey="Kazembe P" first="Peter N." last="Kazembe">Peter N. Kazembe</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Hesseling, Peter B" sort="Hesseling, Peter B" uniqKey="Hesseling P" first="Peter B." last="Hesseling">Peter B. Hesseling</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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